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Progress on molecular biomarkers and classification of malignant gliomas

Chuanbao Zhang, Zhaoshi Bao, Wei Zhang, Tao Jiang

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 150-156 doi: 10.1007/s11684-013-0267-1

Abstract: Anaplastic gliomas (WHO grade III) and glioblastomas (WHO grade IV) represent the major groups of malignantSeveral diagnostic, predictive, and prognostic biomarkers for malignant gliomas have been reported overbiomarkers, three most commonly altered pathways, and three classifications based on microarray data in malignant

Keywords： malignant glioma     molecular biomarker     IDH1     MGMT     molecular classification    

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Molecular targeted therapy of gynecological malignant tumors: the development and challenge, from laboratory

Pengming SUN PhD, MD , Jalid SEHOULI PhD, MD , Lihui WEI BM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 256-264 doi: 10.1007/s11684-009-0052-3

Abstract: More and more molecular drugs based on targeted therapy have been utilized in the treatment of gynecologic cancer, especially in ovarian cancer. In this article, we systematically review the current targeted therapeutic trials running in clinic. Large, randomized trials have been conducted in the treatment of ovarian cancer, endometrial cancer and cervical cancer by using small molecule, antisense, mutational gene as well as antibodies. Other planned or ongoing trials currentlytargeted at molecular markers which may play important roles in gynecological carcinogenesis andprogression suggest that combination chemotherapy with molecular targeted therapy will ultimately be an importantoption.

Keywords： target therapy     gynecologic malignant tumors     clinical trail     molecular medicine    

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Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 240-262 doi: 10.1007/s11684-022-0936-z

Abstract: using cohorts of bulk samples, paired primary and recurrent samples, multi-region samples from the same gliomaMalignant cells in the EM and PM gliomas were correlated to neural stem cell and oligodendrocyte progenitor

Keywords： glioma progression     molecular classification     EM/PM subtyping     intratumor heterogeneity    

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Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell

Frontiers of Medicine doi: 10.1007/s11684-023-1017-7

Abstract: The association of neurogenesis and gliogenesis with glioma remains unclear.Furthermore, the two subgroups appeared to extensively modulate glioma-infiltrating lymphocytes in distinctSome specific genes not expressed in normal immune cells were found in glioma-infiltrating lymphocytesFor example, glial/glioma stem cell markers OLIG1/PTPRZ1 and B cell-specific receptorsIGLC2/IGKC were expressed in pri-OPC-like and RG-like glioma-infiltrating lymphocytes,

Keywords： single-cell RNA-seq     glioma     radial glia     primitive oligodendrocyte precursor cell     immune escape    

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RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 143-155 doi: 10.1007/s11684-022-0929-y

Abstract: However, whether RGS16 can promote the progression of glioma and whether it is regulated by miR let-7cHere, we confirmed that RGS16 is upregulated in glioma tissues and that high expression of RGS16 is associatedEctopic deletion of RGS16 significantly suppressed glioma cell proliferation and migration both inThus, we suggest that the suppression of RGS16 by miR let-7c-5p can promote glioma progression and mayserve as a potential prognostic biomarker and therapeutic target in glioma.

Keywords： RGS16     let-7c-5p     glioma     proliferation     migration    

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Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and

Zhaoshi Bao, Yongzhi Wang, Qiangwei Wang, Shengyu Fang, Xia Shan, Jiguang Wang, Tao Jiang

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 551-561 doi: 10.1007/s11684-020-0760-2

Abstract: Glioma is the most common lethal tumor of the human brain.The median survival of patients with primary World Health Organization grade IV glioma is only 14.6 monthsThe underlying mechanism of glioma recurrence and evolution patterns of glioma are different from thoseHowever, the detailed reasons for the progression and recurrence of glioma remain controversial.In this review, we introduce the different mechanisms involved in glioma progression, including tumor

Keywords： glioma     evolution mechanism     strategies     tumor heterogeneity     secondary glioma    

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Characterizing Thermal Augmentation of Convection-Enhanced Drug Delivery with the Fiberoptic Microneedle Device Article

R. Lyle Hood,Rudy T. Andriani,Tobias E. Ecker,John L. Robertson,Christopher G. Rylander

Engineering 2015, Volume 1, Issue 3,   Pages 344-350 doi: 10.15302/J-ENG-2015077

Abstract:

Convection-enhanced delivery (CED) is a promising technique leveraging pressure-driven flow to increase penetration of infused drugs into interstitial spaces. We have developed a fiberoptic microneedle device for inducing local sub-lethal hyperthermia to further improve CED drug distribution volumes, and this study seeks to quantitatively characterize this approach in agarose tissue phantoms. Infusions of dye were conducted in 0.6% (w/w) agarose tissue phantoms with isothermal conditions at 15 °C, 20 °C, 25 °C, and 30 °C. Infusion metrics were quantified using a custom shadowgraphy setup and image-processing algorithm. These data were used to build an empirical predictive temporal model of distribution volume as a function of phantom temperature. A second set of proof-of-concept experiments was conducted to evaluate a novel fiberoptic device capable of generating local photothermal heating during fluid infusion. The isothermal infusions showed a positive correlation between temperature and distribution volume, with the volume at 30 °C showing a 7-fold increase at 100 min over the 15 °C isothermal case. Infusions during photothermal heating (1064 nm at 500 mW) showed a similar effect with a 3.5-fold increase at 4 h over the control (0 mW). These results and analyses serve to provide insight into and characterization of heat-mediated enhancement of volumetric dispersal.

Keywords： near-infrared laser     thermochemotherapy     agarose     photothermal heating     micro-catheter     malignant glioma    

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Change and significance of T-cell subsets and TNF-α in patients with advanced malignant obstructive jaundice

ZHU Lidong, CHEN Xiaoping

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 364-368 doi: 10.1007/s11684-007-0070-y

Abstract: The aim of this article was to study the influence of immunity function of advanced malignant obstructive
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The Preliminary Study On Malignant Tumors Effects of High Intensive Focused Ultrasound——A Primary ClinicalReport On 78 Cases of Malignant Turmors in HIFU Therapy

He Shenxu,Xiong Liulin,Yu Jinsheng,Lan Jiang

Strategic Study of CAE 1999, Volume 1, Issue 2,   Pages 62-66

Abstract: Methods 78 cases malignant tumors in abdomen and pelvis were classified into two groups： hollow organicConclusions The HIFU is a kind of safe and effective method to treat abdominal malignant tumor, worth

Keywords： malignant tumor     pyrotherapy     extracorporeal focused     ultrasound    

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monoamine transporter 2 genes for increased retention of metaiodobenzylguanidine labeled with iodine 131 in malignant

Yanlin Zhao,Xiao Zhong,Xiaohong Ou,Huawei Cai,Xiaoai Wu,Rui Huang

Frontiers of Medicine 2017, Volume 11, Issue 1,   Pages 120-128 doi: 10.1007/s11684-017-0501-3

Abstract:

Norepinephrine transporter (NET) transfection leads to significant uptake of iodine-131-labeled metaiodobenzylguanidine (131I-MIBG) in non-neuroendocrine tumors. However, the use of 131I-MIBG is limited by its short retention time in target cells. To prolong the retention of 131I-MIBG in target cells, we infected hepatocarcinoma (HepG2) cells with Lentivirus-encoding human NET and vesicular monoamine transporter 2 (VMAT2) genes to obtain NET-expressing, NET-VMAT2-coexpressing, and negative-control cell lines. We evaluated the uptake and efflux of 131I-MIBG both in vitro and in vivo in mice bearing transfected tumors. NET-expressing and NET-VMAT2-coexpressing cells respectively showed 2.24 and 2.22 times higher 131I-MIBG uptake than controls. Two hours after removal of 131I-MIBG-containing medium, 25.4% efflux was observed in NET-VMAT2-coexpressing cells and 38.6% in NET-expressing cells. In vivo experiments were performed in nude mice bearing transfected tumors; results revealed that NET-VMAT2-coexpressing tumors had longer 131I-MIBG retention time than NET-expressing tumors. Meanwhile, NET-VMAT2-coexpressing and NET-expressing tumors displayed 0.54% and 0.19%, respectively, of the injected dose per gram of tissue 24 h after 131I-MIBG administration. Cotransfection of HepG2 cells with NET and VMAT2resulted in increased 131I-MIBG uptake and retention. However, the degree of increase was insufficient to be therapeutically effective in target cells.

Keywords： norepinephrine transporter     vesicular monoamine transporter 2     -MIBG     gene therapy     lentivirus vector    

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Construction of 6HRE-GFAP-Baxα system specific for glioma gene therapy

TIAN Yongji, LI Guilin, GAO Jun, WANG Renzhi, KONG Yanguo, ZHANG Zhenxing, LI Shifang, TIAN Shiqiang, DOU Wanchen, ZHANG Bo

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 49-53 doi: 10.1007/s11684-007-0010-x

Abstract: The aim of this paper is to construct a specific and high-performance gene therapy system for glioma.and then constructed GFAP-Baxα gene expressing system and determined its promoting of apoptosis in gliomaThe glioma cells showed typical apoptotic signs 90 hours after the transient transfection of GFAP-BaxαIn these primary experiments, it showed that 6HRE-GFAPBaxα system could promote glioma cell apoptosisIt was specific and effective for glioma gene therapy.

Keywords： GFAP-Baxα     BT325     Fibrillary     apoptotic     specificity    

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Relationship of adrenomedullin expression and microvessel density and prognosis in smooth muscle tumor of uterus

JIANG Yuan, TIAN Xuehong, YUAN Jie, JIN Yuemei, TAN Yusong

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 398-400 doi: 10.1007/s11684-007-0077-4

Abstract: The ADM can be used as an accessory marker in estimating the malignant potency of LE and judging the

Keywords： anticarcinogenic     microvessel density     malignant potency     muscle     uterine leiomyosarcoma    

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Experimental study on BPA uptake of glioma cell lines

Yang Lei,Wang Xiao,Sui Li,Kong Fuquan,Hao Xiaojuan,Zheng Jieying,Ma Nanru,Cui Suzhen,Liu Quanwei,Zhao Kui

Strategic Study of CAE 2012, Volume 14, Issue 8,   Pages 85-90

Abstract:

Objective: to evaluate the incorporation of BPA by glioma cell lines,cells was increasing with the increasing concentration of BPA, and the boron concentration ratios of gliomaConclusion: BPA has a selectivity for glioma cells, and the results of the efflux assay confirm the temperature

Keywords： boron neutron capture therapy     BPA     glioma cell line     ICP AES    

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Boron neutron capture therapy for glioblastoma of prospects and confused

Zhou Youxin,Sun Ting,Yang Weilian,Du Ziwei

Strategic Study of CAE 2012, Volume 14, Issue 8,   Pages 82-84

Abstract:

Boron neutron capture therapy (BNCT) is a selective radiotherapy of damage tumor cells, and α particle produced by which is effective to prevent glioblastoma multiform recurrence. Clinical trails of BNCT were carried out in fifties to sixties of 20 century in developed countries, but it was limited because of the development of boron carrier and neutron source. This is a review of BNCT prospect on glioblastoma multiform.

Keywords： boron neutron capture therapy     glioblastoma multiform     glioma stem cells    

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Neutron capture therapy clinical development in the world

Zhang Zichu,Jin Congjun,Liu Kai,Zhang Guozhen,Yang Lijun

Strategic Study of CAE 2012, Volume 14, Issue 8,   Pages 100-105

Abstract: The BNCT clinical treatment situation and evaluation in glioblastoma (GBM), malignant melanoma, recurrent

Keywords： BNCT     GBM     malignant melanoma     recurent head & neck cancer     metastatic liver cancer    

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Title Author Date Type Operation

Progress on molecular biomarkers and classification of malignant gliomas

Chuanbao Zhang, Zhaoshi Bao, Wei Zhang, Tao Jiang

Journal Article

Molecular targeted therapy of gynecological malignant tumors: the development and challenge, from laboratory

Pengming SUN PhD, MD , Jalid SEHOULI PhD, MD , Lihui WEI BM ,

Journal Article

Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma

Journal Article

Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell

Journal Article

RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway

Journal Article

Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and

Zhaoshi Bao, Yongzhi Wang, Qiangwei Wang, Shengyu Fang, Xia Shan, Jiguang Wang, Tao Jiang

Journal Article

Characterizing Thermal Augmentation of Convection-Enhanced Drug Delivery with the Fiberoptic Microneedle Device

R. Lyle Hood,Rudy T. Andriani,Tobias E. Ecker,John L. Robertson,Christopher G. Rylander

Journal Article

Change and significance of T-cell subsets and TNF-α in patients with advanced malignant obstructive jaundice

ZHU Lidong, CHEN Xiaoping

Journal Article

The Preliminary Study On Malignant Tumors Effects of High Intensive Focused Ultrasound——A Primary ClinicalReport On 78 Cases of Malignant Turmors in HIFU Therapy

He Shenxu,Xiong Liulin,Yu Jinsheng,Lan Jiang

Journal Article

monoamine transporter 2 genes for increased retention of metaiodobenzylguanidine labeled with iodine 131 in malignant

Yanlin Zhao,Xiao Zhong,Xiaohong Ou,Huawei Cai,Xiaoai Wu,Rui Huang

Journal Article

Construction of 6HRE-GFAP-Baxα system specific for glioma gene therapy

TIAN Yongji, LI Guilin, GAO Jun, WANG Renzhi, KONG Yanguo, ZHANG Zhenxing, LI Shifang, TIAN Shiqiang, DOU Wanchen, ZHANG Bo

Journal Article

Relationship of adrenomedullin expression and microvessel density and prognosis in smooth muscle tumor of uterus

JIANG Yuan, TIAN Xuehong, YUAN Jie, JIN Yuemei, TAN Yusong

Journal Article

Experimental study on BPA uptake of glioma cell lines

Yang Lei,Wang Xiao,Sui Li,Kong Fuquan,Hao Xiaojuan,Zheng Jieying,Ma Nanru,Cui Suzhen,Liu Quanwei,Zhao Kui

Journal Article

Boron neutron capture therapy for glioblastoma of prospects and confused

Zhou Youxin,Sun Ting,Yang Weilian,Du Ziwei

Journal Article

Neutron capture therapy clinical development in the world

Zhang Zichu,Jin Congjun,Liu Kai,Zhang Guozhen,Yang Lijun

Journal Article